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Does size of thyroid nodule indicate cancer? Six percent of the nodules 1 to 1.9 cm were considered suspicious, as were 8 to 9% of nodules in the larger size groups. The prevalence of cancer in relation to nodule size was 10.5% of those 1.0 to 1.9 cm, 13.5% of those 2.0 to 2.9 cm, 16.3% of those 3.0 to 3.9 cm, and 15.0% of those ≥4.0 cm.